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Scrapie
has been recognised as a sheep disease for over 200 years
but recent advances in micro-biology have identified the
causative agent as an abnormal protein fibril or prion occuring
in nervous tissue where it produces changes, especially
in the brain which are similar to B.S.E. All protein production
is controlled by D.N.A. codons. All animals which code ARR/ARR
(type
R1) have full resistance; those which code VRQ/VRQ (type
R5) have least resistance and may develop scrapie as they
age. Transfer of prions from sheep to sheep is not fully
understood although ewes may transfer the abnormal protein
to their lambs during lambing.
During
2002 the National Scrapie Plan (NSP) for the UK was established.
Stock rams used in pure bred registered and non-registered
flocks will be blood tested together with ram lambs to be
used for breeding, flock ewes and ewe lambs to a minimum
number of animals (40) for a cost effective visit.
A contract
for the Rumwell Flock was signed in Summer 2002. This will
run initially for 3 years.
An EID
device in the form of a ruminal bolus is administered at
the time of sampling and the EID number appears on the Genotype
certificate with the result of the test.

Blood sample taken for genotype testing
Certificates
issued for rams indicate the limitations to breeding if
it is not type R1or R2.
For
ewes, certifcates are only issued for type R1 and R2 but
there is no requirement to cull ewes carrying the VRQ gene.
Genotyping
will be carried out in early April at Rumwell so that 8
week old lambs will be tested. Several breeding ewes are
typed R4
Stock
rams used in the flock this year are all typed R1 except
Peridot JER P17 who is type R4 and at 8 years old is still
very active!
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