| 2011-08-14 | West Bromwich A. | A | 2-1 | Rooney, Reid (og) | 25,360 |
| 2011-08-22 | Tottenham H. | H | 3-0 | Rooney, Welbeck, Anderson | 75,498 |
| 2011-08-28 | Arsenal | H | 8-2 | Rooney 3, Welbeck, Young 2, Nani, Park | 75,448 |
| 2011-09-10 | Bolton W. | A | 5-0 | Rooney 3, Hernandez 2 | 25,944 |
| 2011-09-14 | Benfica (CL) | A | 1-1 | Giggs | 59,671 |
| 2011-09-18 | Chelsea | H | 3-1 | Rooney, Nani, Smalling | 75,455 |
| 2011-09-20 | Leeds U. (LC3) | A | 3-0 | Owen 2, Giggs | 31,031 |
| 2011-09-24 | Stoke C. | A | 1-1 | Nani | 27,582 |
| 2011-09-27 | FC Basel (CL) | H | 3-3 | Welbeck 2, Young | 73,115 |
| 2011-10-01 | Norwich C. | H | 2-0 | Welbeck, Anderson | 75,514 |
| 2011-10-15 | Liverpool | A | 1-1 | Hernandez | 45,065 |
| 2011-10-18 | Otelul Galati (CL) | A | 2-0 | Rooney (2 pens) | 49,500 |
| 2011-10-23 | Manchester C. | H | 1-6 | Fletcher | 75,487 |
| 2011-10-25 | Aldershot (LC4) | A | 3-0 | Berbatov, Owen, Valencia | 7,044 |
| 2011-10-29 | Everton | A | 1-0 | Hernandez | 35,494 |
| 2011-11-02 | Otelul Galati (CL) | H | 2-0 | Valencia, Sarghi (og) | 74,847 |
| 2011-11-05 | Sunderland | H | 1-0 | Brown (og) | 75,570 |
| 2011-11-19 | Swansea C. | A | 1-0 | Hernandez | 20,295 |
| 2011-11-22 | Benfica (CL) | H | 2-2 | Berbatov, Fletcher | 74,853 |
| 2011-11-26 | Newcastle U. | H | 1-1 | Hernandez | 75,594 |
| 2011-11-30 | Crystal P. (LC5) | H | 1-2 | Macheda (pen) | 52,624 |
| 2011-12-03 | Aston V. | A | 1-0 | Jones | 40,053 |
| 2011-12-07 | FC Basel (CL) | A | 1-2 | Jones | 36,894 |
| 2011-12-10 | Wolverhampton W. | H | 4-1 | Rooney 2, Nani 2 | 75,627 |
| 2011-12-18 | QPR | A | 2-0 | Rooney, Carrick | 18,033 |
| 2011-12-21 | Fulham | A | 5-0 | Rooney, Nani, Welbeck, Giggs, Berbatov | 25,700 |
| 2011-12-26 | Wigan A. | H | 5-0 | Berbatov 3 (1 pen), Valencia, Park | 75,183 |
| 2011-12-31 | Blackburn R. | H | 2-3 | Berbatov 2 | 75,146 |
| 2012-01-04 | Newcastle U. | A | 0-3 | | 52,299 |
| 2012-01-08 | Manchester C. (FAC3) | A | 3-2 | Rooney 2, Welbeck | 46,808 |
| 2012-01-14 | Bolton W. | H | 3-0 | Welbeck, Scholes, Carrick | 75,444 |
| 2012-01-22 | Arsenal | A | 2-1 | Welbeck, Valencia | 60,093 |
| 2012-01-28 | Liverpool (FAC4) | A | 1-2 | Park | 43,952 |
| 2012-01-31 | Stoke C. | H | 2-0 | Hernandez (pen), Berbatov (pen) | 74,719 |
| 2012-02-05 | Chelsea | A | 3-3 | Rooney (2 pens), Hernandez | 41,668 |
| 2012-02-11 | Liverpool | H | 2-1 | Rooney 2 | 74,844 |
| 2012-02-16 | Ajax (EL) | A | 2-0 | Hernandez, Young | 51,000 |
| 2012-02-23 | Ajax (EL) | H | 1-2 | Hernandez | 67,328 |
| 2012-02-26 | Norwich C. | A | 2-1 | Scholes, Giggs | 26,811 |
| 2012-03-04 | Tottenham H. | A | 3-1 | Rooney, Young 2 | 36,034 |
| 2012-03-08 | Athletic Bilbao (EL) | H | 2-3 | Rooney 2 (1 pen) | 59,265 |
| 2012-03-11 | West Bromwich A. | H | 2-0 | Rooney 2 (1 pen) | 75,598 |
| 2012-03-15 | Athletic Bilbao (EL) | A | 1-2 | Rooney | 40,000 |
| 2012-03-18 | Wolverhampton W. | A | 5-0 | Hernandez 2, Welbeck, Valencia, Evans | 27,494 |
| 2012-03-26 | Fulham | H | 1-0 | Rooney | 75,570 |
| 2012-04-02 | Blackburn R. | A | 2-0 | Valencia, Young | 26,532 |
| 2012-04-08 | QPR | H | 2-0 | Rooney (pen), Scholes | 75,505 |
| 2012-04-11 | Wigan A. | A | 0-1 | | 18,115 |
| 2012-04-15 | Aston V. | H | 4-0 | Rooney 2 (1 pen), Welbeck, Nani | 75,138 |
| 2012-04-22 | Everton | H | 4-4 | Rooney 2, Welbeck, Nani | 75,522 |
| 2012-04-30 | Manchester C. | A | 0-1 | | 47,259 |
| 2012-05-06 | Swansea C. | H | 2-0 | Scholes, Young | 75,496 |
| 2012-05-13 | Sunderland | A | 1-0 | Rooney | 46,452 |