| No. | Day | Date | Home | Score | Away | Competition | Attendance |
|---|---|---|---|---|---|---|---|
| 1 | Sat | 9/7/05 | Mildenhall Town | 0-3 | Cambridge Utd | Friendly | ??? |
| 2 | Wed | 13/7/05 | Cambridge Utd | 0-3 | Ipswich Town | Ian Darler Testimonial | ??? |
| 3 | Sat | 23/7/05 | Cambridge Utd | 1-1 | Gillingham | Friendly | 870 |
| 4 | Tue | 2/8/05 | Cambridge Utd | 2-1 | Nottigham Forest XI | Friendly | ??? |
| 5 | Tue | 9/8/05 | Huntingdon Town | 1-3 | Cambridge Utd | Friendly | ??? |
| 6 | Sat | 13/8/05 | Forest Green Rovers | 1-0 | Cambridge Utd | Conference | 1112 |
| 7 | Tue | 16/8/05 | Cambridge Utd | 2-1 | Hereford Utd | Conference | 2924 |
| 8 | Sat | 20/8/05 | Cambridge Utd | 3-1 | Accrington Stanley | Conference | 2730 |
| 9 | Sat | 27/8/05 | Gravesend and Northfleet | 0-0 | Cambridge Utd | Conference | 1379 |
| 10 | Mon | 29/8/05 | Cambridge Utd | 0-2 | Kidderminster Harriers | Conference | 3161 |
| 11 | Sat | 17/9/05 | Cambridge Utd | 0-2 | Woking | Conference | 2345 |
| 12 | Tue | 20/9/05 | Grays Athletic | 5-3 | Cambridge Utd | Conference | 1543 |
| 13 | Sat | 24/9/05 | Cambridge Utd | 4-0 | Altrincham | Conference | 2199 |
| 14 | Tue | 27/9/05 | Cambridge Utd | 2-2 | Burton Albion | Conference | 2298 |
| 15 | Sat | 1/10/05 | Southport | 2-2 | Cambridge Utd | Conference | 1204 |
| 16 | Fri | 7/10/05 | Cambridge Utd | 2-1 | Tamworth | Conference | 2606 |
| 17 | Tue | 18/10/05 | Cambridge Utd | 3-0 | Chester City | LDV 1 | 1224 |
| 18 | Sat | 29/10/05 | Cambridge Utd | 2-1 | Crawley Town | Conference | 2413 |
| 19 | Sat | 12/11/05 | Morecambe | 0-1 | Cambridge Utd | Conference | 1648 |
| 20 | Tue | 15/11/05 | Newmarket Town | 0-1 | Cambridge Utd XI | Friendly | ??? |
| 21 | Sat | 19/11/05 | Cambridge Utd | 0-2 | Aldershot Town | Conference | 2905 |
| 22 | Tue | 22/11/05 | Cambridge Utd | 3-2 | Doncaster Rovers | LDV 2 | 1435 |
| 23 | Sat | 26/11/05 | Canvey Island | 1-1 | Cambridge Utd | Conference | 842 |
| 24 | Sat | 3/12/05 | Cambridge Utd | 2-1 | Scarborough | Conference | 2809 |
| 25 | Sat | 10/12/05 | Dagenham and Redbridge | 1-0 | Cambridge Utd | Conference | 1271 |
| 26 | Thu | 29/12/05 | Feyenoord Rotterdam | 6-1 | Willem II | Eredivisie | c40000 |
| 27 | Sat | 31/12/05 | Cambridge Utd | 3-1 | Canvey Island | Conference | 2594 |
| 28 | Mon | 2/1/06 | Stevenage Borough | 3-1 | Cambridge Utd | Conference | 3463 |
| 29 | Sat | 7/1/06 | Cambridge Utd | 2-2 | Forest Green | Conference | 2344 |
| 30 | Sat | 21/1/06 | Accrington Stanley | 1-0 | Cambridge Utd | Conference | 1837 |
| 31 | Sat | 28/1/06 | Cambridge Utd | 1-1 | Gravesend and Northfleet | Conference | 2344 |
| 32 | Fri | 3/2/06 | Bishop's Stortford | 1-0 | Cambridge Utd | Friendly | 168 |
| 33 | Sat | 11/2/06 | Altrincham | 2-1 | Cambridge Utd | Conference | 1151 |
| 34 | Mon | 13/2/06 | Mildenhall Town | 3-2 | Cambridge Utd XI | Friendly | ??? |
| 35 | Wed | 15/2/06 | England National Game XI | 3-1 | Italy | European Challenge Trophy @Abbey Stadium, Cambridge | 2711 |
| 36 | Sat | 18/2/06 | Cambridge Utd | 2-1 | Southport | Conference | 2310 |
| 37 | Tue | 21/2/06 | Burton Albion | 2-0 | Cambridge Utd | Conference | 1577 |
| 38 | Sat | 4/3/06 | Woking | 0-1 | Cambridge Utd | Conference | 2066 |
| 39 | Tue | 7/3/06 | Cambridge Utd | 1-1 | Grays Athletic | Conference | 1821 |
| 40 | Sat | 11/3/06 | Tamworth | 1-1 | Cambridge Utd | Conference | 1325 |
| 41 | Sat | 18/3/06 | Cambridge Utd | 1-1 | Halifax | Conference | 2288 |
| 42 | Sat | 1/4/06 | Cambridge Utd | 2-2 | Morecambe | Conference | 2129 |
| 43 | Tue | 4/4/06 | Cambridge Utd | 2-1 | Exeter City | Conference | 2358 |
| 44 | Sat | 8/4/06 | Aldershot Town | 1-3 | Cambridge Utd | Conference | 2198 |
| 45 | Fri | 14/4/06 | Cambridge Utd | 2-0 | York City | Conference | 3188 |
| 46 | Sat | 22/4/06 | Scarborough | 1-2 | Cambridge Utd | Conference | 1831 |
| 47 | Sat | 29/4/06 | Cambridge Utd | 1-2 | Dagenham & Redbridge | Conference | 3161 |