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Across
1 Crustacean that wears a cast-off mollusc shell (6,4)
6 Compound used in rat poison, also to treat thrombosis (8)
12 What DOS stands for (4,9,6)
13 A set of moral principles (5)
14 Bronze-age Cretan city, home of the mythical Minotaur (7)
15 Second largest of the zodiacal constellations (5)
16 The sign '&' (9)
17 Subatomic particle with almost zero mass (8)
20 United Arab countries – national capital Dubai (8)
22 Athlete competing in contest with ten events (10)
25 Person fallen from the normal moral standard (10)
27 Shakespeare's tragic sovereign (4,4)
30 Name of the pre-Roman civilization in modern-day Tuscany / part of Umbria (8)
32 Written expositions considering their subject matter in a systematic and in-depth manner (9)
35 6C BC Greek writer of fables (5)
37 Shakespearean lover rejected by Hamlet (7)
38 Middle Eastern, N. African ruler – found in extreme Eritrea? (not usual spelling) (5)
39 Illness involving progressive degeneration of nerve cells and muscles (5,7,7)
40 Heavenly body such as Polaris, used as navigational aid (8)
41 Cancer-causing substance (10)
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Down
1 The real, undisclosed motive(s) behind a discussion, programme of action etc. (6,6)
2 The fruit of a thorny-stemmed flower (4,3)
3 Churchill's metaphorical phrase for the barrier to communications in the Cold War (4,7)
4 Inescapable chess position for a king (9)
5 South American boa (8)
7 Aromatic bitter bark used as flavouring for alcoholic drinks (9)
8 Bridge carrying a road over another – or ceremonial flight of aircraft (7)
9 Set of revolving blades that lift a helicopter (5)
10 Legendary mighty hunter and name of one of Elgar's Enigma Variations (6)
11 German-born US diplomat and Nobel Peace Prize winner 1973 (9)
18 What Queen Victoria was to William IV (5)
19 One who operates on e.g. brain and spinal cord (12)
21 Piece of cast gold (5)
23 Violation of allegiance to one's sovereign or state (4,7)
24 Foul-smelling fungus (9)
26 e.g Tommy or Quadrophenia by the Who (4,5)
28 Language of N. Atlantic island people (9)
29 Greek mythological huntress who challenged suitors to a race (8)
31 Sports officials enforcing rules and settling disputes (7)
33 Everything involved in a set-up (usually in the phrase "the whole __") (7)
34 Mount in Israel after which a contemplative order is named (6)
36 Of a desire or appetite, fully indulged (5)
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